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Prednisolone is a synthetic glucocorticosteroid drug, a dehydrated analog of hydrocortisone. Has anti-inflammatory, antiallergic, immunosuppressive action, increases the sensitivity of beta-adrenoreceptors to endogenous catecholamines buy prednisone online.
Interacts with specific cytoplasmic receptors (receptors for glucocorticosteroids (GCS) are present in all tissues, especially in the liver), with the formation of a complex inducing the formation of proteins (including enzymes that regulate vital processes in cells generic prednisone cost.) Protein metabolism: reduces the number of globulins in the plasma, increases the synthesis of albumins in the liver and kidneys (with increasing albumin / globulin ratio), reduces synthesis and enhances protein catabolism in muscle tissue buy prednisone online over the counter.
Lipid metabolism: increases synthesis of higher fatty acids and triglycerides, redistributes fat (accumulation of fat occurs mainly in the area of the shoulder girdle, face, abdomen), leads to the development of hypercholesterolemia prednisone for sale. Carbohydrate metabolism: increases the absorption of carbohydrates from the gastrointestinal tract; Increases the activity of glucose-6-phosphatase (increased intake of glucose from the liver into the blood); Increases the activity of phosphoenolpyruvate carboxylase and the synthesis of aminotransferases (activation of gluconeogenesis); Promotes the development of hyperglycemia.
Water-electrolytic exchange: retards sodium and water in the body, stimulates the excretion of potassium (mineralocorticoid activity), reduces the absorption of buy prednisone online without prescription calcium from the gastrointestinal tract, reduces the mineralization of bone tissue.
The anti-inflammatory effect is associated with the suppression of the release of eosinophils and mast cells by inflammatory mediators; Inducing the formation of lipocortins and reducing the number of mast cells that produce hyaluronic acid; With a decrease in capillary permeability; Stabilization of cell membranes (especially lysosomal) and membranes of organelles. It acts on all stages of the inflammatory process: it inhibits the synthesis of prostaglandins at the level of arachidonic acid (lipocortin depresses phospholipase A2, suppresses the liberation of arachidonic acid buy prednisone online over the counter and inhibits the biosynthesis of endoperexides, leukotrienes, promoting inflammation, allergies, etc.), the synthesis of pro-inflammatory cytokines (interleukin 1, Tumor necrosis factor alpha, etc.); Increases the resistance of the cell membrane to the action of various damaging factors prednisone cost. Immunosuppressive effect is caused by induced lymphoid tissue involution, suppression of lymphocyte proliferation (especially T-lymphocytes), suppression of B-cell migration and interaction of T and B lymphocytes, inhibition of release of cytokines (interleukin-1, 2, gamma-interferon) prednisone for sale from lymphocytes and macrophages And a decrease in the formation of antibodies prednisone over the counter.
The antiallergic effect develops as a result of a decrease in the synthesis and secretion of mediators of allergy, inhibition of release from sensitized mast cells and basophils of histamine and other biologically active substances, a decrease in the number of circulating basophils, T- and B-lymphocytes, mast cells; Inhibition of the development of lymphoid and connective tissue, reduction of the sensitivity of effector cells to mediators of allergy, inhibition of antibody formation, changes in the immune response of the organism. In obstructive airway diseases, the effect is mainly due to the inhibition of inflammatory processes, the prevention or reduction of the degree of edema of the buy prednisone online otc mucous membranes, the decrease in the eosinophilic infiltration of the submucosal layer of the bronchial epithelium and the deposition of circulating immune complexes in the bronchial mucosa, as well as inhibition of erosion and desquamation of the mucosa. Increases the sensitivity of beta-adrenergic receptors of small and medium-sized bronchial tubes to endogenous catecholamines and exogenous sympathomimetics, reduces the viscosity of mucus by reducing its production.
Suppresses the synthesis and secretion of ACTH and, secondarily, the synthesis of endogenous GCS. It inhibits connective tissue reactions during the inflammatory process prednisone over the counter and reduces the possibility of scar tissue formation.
When ingestion, prednisolone is well absorbed from the gastrointestinal tract. The maximum concentration in the blood is reached after 1-1.5 hours after oral administration. Up to 90% of the drug binds to plasma proteins: transcortin (cortisol-binding globulin) and albumins. Prednisolone is metabolized in the liver, partially in the kidneys and other tissues, mainly by conjugation with glucuronic and sulfuric acids. Metabolites are inactive. It is excreted with bile and urine by glomerular filtration and is reabsorbed by tubules by 80-90%. 20% of the dose is excreted by the kidneys unchanged. The half-life from plasma after oral prednisone cost administration is 2-4 hours buy prednisone online no prescription, after intravenous administration, 2-3.5 hours.
Emergency therapy for conditions requiring a rapid increase in glucocorticosteroid concentrations in the body:
For short-term use according to vital indications, the only contraindication is hypersensitivity to prednisolone or the components of the drug prednisone otc for sale online. In children during growth, the SCS should only be used for absolute indications and under the close supervision of the treating physician buy prednisone online. With caution, the drug should be administered in the following conditions and conditions:
During pregnancy (especially in the first trimester) is used only for life indications. With prolonged therapy during pregnancy, the possibility of impaired fetal growth is not ruled out. In the case of use in the III trimester of pregnancy, there is a risk of atrophy of the adrenal cortex in the fetus, which may require replacement therapy over the counter prednisone in the newborn. Since glucocorticosteroids penetrate into breast milk buy prednisone online price cheap, if it is necessary to use the drug during breastfeeding, it is recommended to stop breastfeeding.
The dose of the drug and the duration of treatment is determined by the doctor individually, depending on the indications and severity of the disease prednisone otc. Pills. The whole daily dose of the drug is recommended to take 5mg prednisone a single or double daily dose - every other day, taking into account the circadian rhythm of endogenous secretion of glucocorticosteroids in the interval from 6 to 8 am. A high daily dose can be divided into 2-4 doses, with a large dose taken in the morning. Tablets should be taken during or immediately after meals, with a small amount of liquid. In acute conditions and as a replacement therapy, adults are prescribed purchase prednisone over the counter in an initial dose of 20-30 mg / day, the maintenance dose is 5-10 mg / day. If necessary, the initial dose may be 15-100 mg / day, maintaining -5-15 mg / day.
For children, the initial dose is 1-2 mg / kg of body weight per day in 4-6 receptions, supporting - 300-600 mcg / kg per day. With prolonged use of the drug buy prednisone online over the counter, the daily dose should be reduced gradually. Long-term therapy can not be stopped suddenly! Solution for intravenous and intramuscular injection. Prednisolone for humans is administered intravenously (either by jet or by drip) or by intramuscular injection. Intravenously the drug is usually injected first with a stream, then drip.
The preparation is a ready-made solution. Do not dilute it in any infusion and injection solutions!
In acute adrenal insufficiency prednisone cost, a single dose of the drug is 100-200 mg, daily 300-400 mg. In severe allergic reactions Prednisolone is administered in a daily dose of 100-200 mg for 3-16 days. In bronchial asthma, the drug is administered depending on the severity of the disease and the effectiveness of complex treatment from 75 to 675 mg for a course of treatment of 3 to 16 days; In severe cases, the dose may be increased to 1,400 mg per treatment course and more with a gradual dose reduction.
With asthmatic status non prescription Prednisolone is administered at a dose of 500-1200 mg per day, followed by a decrease to 300 mg per day and transition to maintenance doses buy prednisone online. In thyrotoxic crisis, 100 mg of the drug are administered in a daily dose of 200-300 mg; If necessary, the daily dose can be increased to 1000 mg. The duration of administration depends on the therapeutic effect, usually up to 6 days. In the case of shock resistant to standard therapy, prednisolone is usually injected at the beginning of the therapy, after which it is switched to a drop introduction. If the arterial pressure does not increase within 10-20 minutes 5mg prednisone, repeat the fluid administration of the drug. After excretion from the shock state, the drip administration continues until the blood pressure stabilizes. Single dose is 50-150 mg (in severe cases - up to 400 mg). Repeated drug is administered after 3-4 hours. The daily dose can be 300-1200 mg (with a subsequent dose reduction).
In acute liver-kidney failure (acute poisoning, postoperative and postpartum periods, etc.), prednisolone is administered at 25-75 mg per day buy prednisone online without prescription; In the presence of indications, the daily dose may be increased to 300-1500 mg per day or more. In rheumatoid arthritis and systemic lupus erythematosus Prednisolone is administered in addition to the systemic administration of the drug at a dose of 75 -125 mg per day prednisone no prescription for not more than 7-10 days.
In acute hepatitis Prednisolone is administered at 75-100 mg per day for 7-10 days. When poisoning with cauterizing liquids with burns of the digestive tract and upper respiratory tract Prednisolone is prescribed in a dose of 75-400 mg per day for 3-18 days. If intravenous administration is not possible, Prednisolone is administered intramuscularly in the same doses. After arresting the acute condition, prescribe inside Prednisolone in tablets, followed by a gradual decrease in the dose. With prolonged use of the drug, the daily dose should be reduced gradually. Long-term therapy can not be stopped suddenly buy prednisone online. Side effect. The frequency of development and severity of side effects depends on the duration of the application, the amount of dose used and the possibility of observing the circadian rhythm of prescription of prednisolone. When applying Prednisolone may be noted: On the part of the endocrine system: a decrease in glucose tolerance, steroid diabetes mellitus or manifestation of latent diabetes mellitus, oppression of adrenal function prednisone without prescription, Itenko-Cushing syndrome (lunar face, obesity of the pituitary type, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, muscle weakness, striae) , Delay in sexual development in children over the counter prednisone.
On the part of the digestive system: nausea, vomiting, pancreatitis, steroid ulcer of the stomach and duodenum, erosive esophagitis, gastrointestinal buy prednisone over the counter bleeding and perforation of the gastrointestinal wall, increased or decreased appetite, digestive disorders, flatulence, hiccough. In rare cases - increased activity of liver transaminases and alkaline phosphatase cheap generic prednisone cost. From the cardiovascular system: arrhythmias, bradycardia (up to cardiac arrest); Development (in predisposed patients) or increased manifestation of heart failure, changes in the electrocardiogram, characteristic of hypokalemia, increased blood pressure, hypercoagulation, thrombosis. In patients with acute and subacute myocardial infarction - the spread of the focus of necrosis, slowing the formation of scar tissue, which can lead to rupture of the heart muscle prednisone price cheap. From the nervous system: delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, increased intracranial pressure, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor, cerebral palsy buy cheap prednisone online over the counter, headache, convulsions.
From the sense organs: posterior subcapsular cataract prednisone no prescription, increased intraocular pressure with possible damage to the optic nerve, propensity to develop secondary bacterial, fungal or viral eye infections, trophic corneal changes, exophthalmos, sudden loss of vision (with parenteral administration in the head, neck, nasal Shells, scalp, it is possible to deposit crystals over the counter prednisone of the drug in the vessels of the eye).
On the part of metabolism: increased excretion of calcium, hypocalcemia, weight gain, negative nitrogen balance (increased protein breakdown), increased sweating. Due to mineralocorticoid activity - fluid and sodium retention buy prednisone online (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue). On the part of the musculoskeletal system: slowing growth and ossification processes in children (premature closure of the epiphyseal growth zones prednisone without prescription), osteoporosis (very rarely - pathological bone fractures, aseptic necrosis of the head of the humerus and thighbone), rupture of the tendons of muscles, steroid myopathy, (atrophy). From the skin and mucous membranes: delayed healing of wounds, petechiae, ecchymosis, thinning of the skin, hyper- or hypopigmentation, steroid acne, striae, propensity to develop pyoderma and candidiasis.
Allergic reactions: skin rash, itching, order prednisone online anaphylactic shock, local allergic reactions. Local with parenteral administration: burning prednisone 5 mg pills over the counter, numbness, pain, tingling at the injection site, infections at the injection site, rarely - necrosis of surrounding tissues, scar formation at the injection site; Atrophy of the skin and subcutaneous tissue with the / m introduction (especially dangerous is the introduction to the deltoid muscle). Other: development or exacerbation of infections buy prednisone online (the emergence of this side effect is promoted by jointly used immunosuppressants and vaccination), leukocyturia, withdrawal syndrome, with iv introduction - tides of blood to the face.
It is possible to strengthen the above described side effects. It is necessary to reduce the dose of Prednisolone. Treatment is symptomatic.
The pharmaceutical incompatibility of prednisolone 40mg with other intravenously administered drugs is possible - it is recommended to administer it separately from other drugs (iv bolus, or via another drip as a second solution). When mixing the solution of prednisolone with heparin a precipitate forms. The simultaneous administration of prednisolone with:
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